The COVID-19 pandemic confronts stress researchers in psychology and neuroscience with
unique challenges. Widely used experimental paradigms such as the Trier Social Stress …

Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …

Motivation Polygenic scores have become a central tool in human genetics research.
LDpred is a popular method for deriving polygenic scores based on summary statistics and …

We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …

The diathesis–stress theory for depression states that the effects of stress on the depression
risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects …

Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

EFSA and EMA have jointly reviewed measures taken in the EU to reduce the need for and
use of antimicrobials in food‐producing animals, and the resultant impacts on antimicrobial …

BackgroundMajor depressive disorder (MDD) is a common and disabling condition with well-
established heritability and environmental risk factors. Gene–environment interaction …

Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in
the prediction of disease risks. PRSs are generally constructed as weighted sum scores of …

Abstract Purpose of Review We will describe the success of recent genome-wide
association studies that identify genetic variants associated with depression and outline the …