A comprehensive literature search was performed to collate evidence of mitochondrial
dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features …

Several lines of evidence implicate mitochondria in the pathophysiology of autism spectrum
disorder (ASD). In this review, we outline some of the evidence supporting this notion, as …

Autism spectrum disorder (ASD) affects~ 2% of children in the United States. The etiology of
ASD likely involves environmental factors triggering physiological abnormalities in …

Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders that are defined solely on the basis of behavioral observations. Therefore, ASD …

Autism spectrum disorder (ASD) is a severe neuropsychiatric disease with strong genetic
underpinnings. However, genetic contributions to autism are extremely heterogeneous, with …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …

Until the last decade, studies of the timing of early symptom emergence in autism spectrum
disorder (ASD) relied upon retrospective methods. Recent investigations, however, are …

The cerebral folate receptor alpha (FRα) transports 5-methyltetrahydrofolate (5-MTHF) into
the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). CFD has been …

The Autisms, written by Mary Coleman and Christopher Gillberg, demonstrates that autism,
like mental retardation, is a clinical presentation of numerous different diseases, many with …

J. Neurochem.(2011) 117, 209–220. Abstract Mitochondria play important roles in
generation of free radicals, ATP formation, and in apoptosis. We studied the levels of …