Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …

Venetoclax is a highly selective and effective B-cell lymphoma-2 (BCL-2) inhibitor, which is
able to reinstate the apoptotic potential of cancer cells. With its full repertoire yet to be …

Deregulated cellular apoptosis is a hallmark of cancer and chemotherapy resistance. The B-
cell lymphoma 2 (BCL-2) protein family members are sentinel molecules that regulate the …

Mantle cell lymphoma (MCL), an aggressive, but incurable B-cell lymphoma, is genetically
characterized by the t (11; 14) translocation, resulting in the overexpression of Cyclin D1. In …

Despite the effectiveness of chemoimmunotherapy (CIT), in most cases the clinical course of
chronic lymphocytic leukemia (CLL) is characterized by consecutive episodes of disease …

Simple Summary The phosphoinositide 3-kinase (PI3K) is a family of kinases that play a key
role in the biology of chronic lymphocytic leukemia (CLL). Inhibitors of PI3K demonstrated …

We reviewed the literature (January 2010–June 2021) on the effectiveness of debulking
strategies before venetoclax initiation in patients with chronic lymphocytic leukemia to …

Chronic lymphocytic leukemia (CLL) is frequently associated with autoimmune hemolytic
anemia and immune thrombocytopenia and, less frequently, with pure red cell aplasia and …

Targeted agents have significantly improved outcomes for patients with chronic lymphocytic
leukemia, particularly high-risk subgroups for whom chemoimmunotherapy previously …

Mantle cell lymphoma is a rare B-cell non-Hodgkin's lymphoma that retains a sobering
prognosis despite an extensive research effort. Mantle cell lymphoma remains incurable …