Molecular, pathological, clinical, and therapeutic aspects of perihematomal edema in different stages of intracerebral hemorrhage

C Jiang, H Guo, Z Zhang, Y Wang, S Liu… - Oxidative Medicine …, 2022 - Wiley Online Library
Acute intracerebral hemorrhage (ICH) is a devastating type of stroke worldwide. Neuronal
destruction involved in the brain damage process caused by ICH includes a primary injury …

An ambiguous role for fever in worsening outcome after intracerebral hemorrhage

LJ Liddle, CA Dirks, M Almekhlafi… - Translational Stroke …, 2023 - Springer
Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and leaves most
survivors with impairments. Fever, a rise in the thermoregulatory set point, complicates ICH …

Brain Stroke Lesion Segmentation Using Computed Tomography Images based on Modified U-Net Model with ResNet Blocks.

A Tursynova, B Omarov, A Sakhipov… - … Journal of Online & …, 2022 - search.ebscohost.com
Segmentation of brain regions affected by ischemic stroke helps to overcome the main
obstacles in modern studies of stroke visualization. Unfortunately, contemporary methods of …

Blood biomarker changes following therapeutic hypothermia in ischemic stroke

E Palà, A Penalba, A Bustamante… - Brain and …, 2023 - Wiley Online Library
Introduction Therapeutic hypothermia is a promising candidate for stroke treatment although
its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act …

Disturbed cerebral circulation and metabolism matters: A preface to the special issue “Stroke and Energy Metabolism”

Y Chen - Journal of Neurochemistry, 2022 - Wiley Online Library
Stroke is a serious neurological disorder caused by blockage or rupture of cerebral blood
vessels. Two main aims in acute stroke therapy include the restoration of cerebral blood flow …

A systematic review and meta-analysis on the efficacy of glibenclamide in animal models of intracerebral hemorrhage

TFC Kung, CM Wilkinson, LJ Liddle, F Colbourne - Plos one, 2023 - journals.plos.org
Intracerebral hemorrhage (ICH) is a devastating stroke with many mechanisms of injury.
Edema worsens outcome and can lead to mortality after ICH. Glibenclamide (GLC), a …

Hypothermia protects the integrity of corticospinal tracts and alleviates mitochondria injury after intracerebral hemorrhage in mice

E Sun, S Lu, C Yang, Z Li, Y Qian, Y Chen, S Chen… - Experimental …, 2024 - Elsevier
Disruption of corticospinal tracts (CST) is a leading factor for motor impairments following
intracerebral hemorrhage (ICH) in the striatum. Previous studies have shown that …

A Systematic Review and Meta-Analysis of Therapeutic Hypothermia and Pharmacological Cotherapies in Animal Models of Ischemic Stroke

ACC Suerte, LJ Liddle, A Abrahart… - Therapeutic …, 2024 - liebertpub.com
Therapeutic hypothermia (TH) lessens ischemic brain injury. Cytoprotective agents can
augment protection, although it is unclear which combinations are most effective. The …

Trends and hotspots of the neuroprotection of hypothermia treatment: A bibliometric and visualized analysis of research from 1992 to 2023

Y Zhang, M Jiang, S Baoying, Y Gao… - CNS Neuroscience …, 2024 - Wiley Online Library
Aim Recent studies have extensively investigated hypothermia as a therapeutic approach
for mitigating neural damage. Despite this, bibliometric analyses specifically focusing on this …

Selective brain cooling with a novel catheter reduces infarct growth after recanalization in a canine large vessel occlusion model

RM King, V Anagnostakou… - Interventional …, 2024 - journals.sagepub.com
Background Therapeutic hypothermia has shown potential in cardiac intervention for years;
however, its adoption into the neurovascular space has been limited. Studies have pointed …