Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Strict spatiotemporal control of trafficking events between organelles is critical for
maintaining homeostasis and directing cellular responses. This regulation is particularly …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Recycling endosomes are stations that sort endocytic cargoes to their appropriate
destinations. Tubular endosomes have been characterized as a recycling endosomal …

Rab GTPases are important regulators of intracellular membrane trafficking in eukaryotes.
Both activating and inactivating mutations in Rab genes have been identified and implicated …

Background Parkinson's disease is a progressive neurodegenerative disorder with
multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are …

Intracellular bacterial pathogens survive and replicate within specialized eukaryotic cell
organelles. To establish their intracellular niches these pathogens have adopted …

Salmonella enterica is the leading cause of bacterial foodborne illness in the USA, with an
estimated 95% of salmonellosis cases due to the consumption of contaminated food …

Lysosome-related organelles (LROs) are specialized lysosomes with cell type–specific roles
in organismal homeostasis. Dysregulation of LROs leads to many human disorders, but the …

The Rab family of small GTPases regulate various aspects of cellular dynamics in eukaryotic
cells. Membrane trafficking has emerged as central to the functions of leucine-rich repeat …