Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

Inflammation involving the innate and adaptive immune systems is a normal response to
infection. However, when allowed to continue unchecked, inflammation may result in …

Epigenetic changes such as DNA methylation and histone methylation and acetylation alter
gene expression at the level of transcription by upregulating, downregulating, or silencing …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

Cerebral palsy is caused by injury or developmental disturbances to the immature brain and
leads to substantial motor, cognitive, and learning deficits. In addition to developmental …