Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
Physicochemical regulation of biofilm formation
This article reviews the physical and chemical constraints of environments on biofilm
formation. We provide a perspective on how materials science and engineering can address …
formation. We provide a perspective on how materials science and engineering can address …
Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures
To dissect the antibiotic role of nanostructures from chemical moieties belligerent to both
bacterial and mammalian cells, here we show the antimicrobial activity and cytotoxicity of …
bacterial and mammalian cells, here we show the antimicrobial activity and cytotoxicity of …
Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …
highly engage into research on alternative strategies to the traditional small molecule …
Dual mechanism β-amino acid polymers promoting cell adhesion
Q Chen, D Zhang, W Zhang, H Zhang, J Zou… - Nature …, 2021 - nature.com
Cell adhesion has tremendous impact on the function of culture platforms and implants. Cell-
adhesive proteins and peptides have been extensively used for decades to promote cell …
adhesive proteins and peptides have been extensively used for decades to promote cell …
Recent synthetic transport systems
S Matile, AV Jentzsch, J Montenegro… - Chemical Society Reviews, 2011 - pubs.rsc.org
This critical review covers progress with synthetic transport systems, particularly ion
channels and pores, between January 2006 and December 2009 in a comprehensive …
channels and pores, between January 2006 and December 2009 in a comprehensive …
Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold
B Findlay, GG Zhanel, F Schweizer - Antimicrobial agents and …, 2010 - Am Soc Microbiol
Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse
class of antibacterial agents currently validated in preclinical and clinical settings for the …
class of antibacterial agents currently validated in preclinical and clinical settings for the …
Positively charged polymers as promising devices against multidrug resistant gram-negative bacteria: A Review
S Alfei, AM Schito - Polymers, 2020 - mdpi.com
Antibiotic resistance has increased markedly in Gram-negative bacteria, causing severe
infections intractable with traditional drugs and amplifying mortality and healthcare costs …
infections intractable with traditional drugs and amplifying mortality and healthcare costs …
Mapping membrane activity in undiscovered peptide sequence space using machine learning
There are some∼ 1,100 known antimicrobial peptides (AMPs), which permeabilize
microbial membranes but have diverse sequences. Here, we develop a support vector …
microbial membranes but have diverse sequences. Here, we develop a support vector …
Helical antimicrobial polypeptides with radial amphiphilicity
α-Helical antimicrobial peptides (AMPs) generally have facially amphiphilic structures that
may lead to undesired peptide interactions with blood proteins and self-aggregation due to …
may lead to undesired peptide interactions with blood proteins and self-aggregation due to …