[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

Association of biochar properties with changes in soil bacterial, fungal and fauna communities and nutrient cycling processes

Z Dai, X Xiong, H Zhu, H Xu, P Leng, J Li, C Tang, J Xu - Biochar, 2021 - Springer
Soil microorganisms play crucial roles in soil nutrient cycling, carbon sequestration, fertility
maintenance and crop health and production. To date, the responses of microorganisms …

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

CN Spencer, JL McQuade, V Gopalakrishnan… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in
cancer, but the effect of diet and supplements on this interaction is not well studied. We …

Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

Y Chen, S Yang, J Tavormina, D Tampe, M Zeisberg… - Cancer cell, 2022 - cell.com
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

RH Mills, PS Dulai, Y Vázquez-Baeza, C Sauceda… - Nature …, 2022 - nature.com
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

[HTML][HTML] Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma

L Dong, D Lu, R Chen, Y Lin, H Zhu, Z Zhang, S Cai… - Cancer cell, 2022 - cell.com
We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

ME Griffin, J Espinosa, JL Becker, JD Luo, TS Carroll… - Science, 2021 - science.org
The antitumor efficacy of cancer immunotherapy can correlate with the presence of certain
bacterial species within the gut microbiome. However, many of the molecular mechanisms …

The gut microbiota is associated with immune cell dynamics in humans

J Schluter, JU Peled, BP Taylor, KA Markey, M Smith… - Nature, 2020 - nature.com
The gut microbiota influences development,–and homeostasis,,–of the mammalian immune
system, and is associated with human inflammatory and immune diseases, as well as …

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

X Zhou, R Baumann, X Gao, M Mendoza, S Singh… - Cell, 2022 - cell.com
Changes in gut microbiota have been associated with several diseases. Here, the
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …

Wildfire-dependent changes in soil microbiome diversity and function

AR Nelson, AB Narrowe, CC Rhoades, TS Fegel… - Nature …, 2022 - nature.com
Forest soil microbiomes have crucial roles in carbon storage, biogeochemical cycling and
rhizosphere processes. Wildfire season length, and the frequency and size of severe fires …