The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …

Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Plants cannot survive without glutathione (γ‐glutamylcysteinylglycine) or γ‐glutamylcysteine‐
containing homologues. The reasons why this small molecule is indispensable are not fully …

Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Polyamines (PAs) are indispensable polycations ubiquitous to all living cells. Among their
many critical functions, PAs contribute to the oxidative balance of the cell. Beginning with …

Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …

Glutathione (GSH) is the major cellular thiol participating in cellular redox reactions and
thioether formation. This article serves as introduction to the FRBM Forum on glutathione …

Twelve years ago, Ralph Adams published an article in ANALYTICAL Chemistry concerning
brain chemis-try (1). He described a number of elec-troanalytical techniques that were be …