Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

How do growing bacterial colonies get their shapes? While colony morphogenesis is well
studied in two dimensions, many bacteria grow as large colonies in three-dimensional (3D) …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

An early step of metastasis requires a complex and coordinated migration of invasive tumor
cells into the surrounding tumor microenvironment (TME), which contains extracellular …

Metastases, or migration of cancers, are common and severe cancer complications.
Although the 5-year survival rates of primary tumors have greatly improved, those of …