Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …

The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to
assemble and maintain the cilium, a long organelle extending from eukaryotic cells that …

Long-distance transport in eukaryotic cells is driven by molecular motors that move along
microtubule tracks. Molecular motors of the kinesin superfamily contain a kinesin motor …

Kinesin-2 was first purified as a heterotrimeric, anterograde, microtubule-based motor
consisting of two distinct kinesin-related subunits and a novel associated protein (KAP) that …

Cilia and flagella serve as cellular antennae and propellers in various eukaryotic cells, and
contain specific receptors and ion channels as well as components of axonemal …

Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like
organelles found on the surface of virtually all human cell types. By delivering proteins to the …

Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia
act as antennae to sense a cell's environment and are involved in a wide range of signaling …

Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of
intracellular movements. Regulation of Kinesin activity and Kinesin-cargo interactions …

Homodimeric KIF17 and heterotrimeric KIF3AB are processive, kinesin-2 family motors that
act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along …

Kinesin-driven organelle transport is crucial for neuron development and maintenance, yet
the mechanisms by which kinesins specifically bind their organelle cargoes remain …