Abstract Background & Aims Preclinical identification of compounds at risk of causing drug
induced liver injury (DILI) remains a significant challenge in drug development, highlighting …

The liver is among the most frequently targeted organs by noxious chemicals of diverse
nature. Liver toxicity testing using laboratory animals not only raises serious ethical …

Introduction Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable
multifactorial condition. At present, validated preclinical models for the prediction of the …

Purpose Cholestatic liver diseases are groups of hepatobiliary diseases without curative
drug-based therapy options. Regulation of bile acid (BA) metabolism, hepatoperiductal …

Background & Aims Idiosyncratic drug-induced liver injury (DILI) is a complex and
unpredictable event caused by drugs, and herbal or dietary supplements. Early identification …

Abstract Background & Aims Knowledge about early hepatitis B virus (HBV) covalently-
closed-circular-DNA (cccDNA) accumulation post-infection is lacking. We characterized and …

Cell-based impedance spectroscopy (CBI) is a powerful tool that uses the principles of
electrochemical impedance spectroscopy (EIS) by measuring changes in electrical …

Human liver organoids derived from primary human hepatocytes (PHHs) are expected to be
a hepatocyte source for preclinical in vitro studies of drug metabolism and disposition …

Aim: To explore the hepatotoxicity of copper sulfide nanoparticles (CuSNPs) toward
hepatocyte spheroids. Materials & methods: Other than the traditional agarose method to …

In vitro models of the human liver are promising alternatives to animal tests for drug
development. Currently, primary human hepatocytes (PHHs) are preferred for …