A glitch in the matrix: The role of extracellular matrix remodeling in opioid use disorder
Opioid use disorder (OUD) and deaths from drug overdoses have reached unprecedented
levels. Given the enormous impact of the opioid crisis on public health, a more thorough, in …
levels. Given the enormous impact of the opioid crisis on public health, a more thorough, in …
The ventral tegmental area and nucleus accumbens as circadian oscillators: implications for drug abuse and substance use disorders
Circadian rhythms convergently evolved to allow for optimal synchronization of individuals'
physiological and behavioral processes with the Earth's 24-h periodic cycling of …
physiological and behavioral processes with the Earth's 24-h periodic cycling of …
Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens
Opioid craving and relapse vulnerability is associated with severe and persistent sleep and
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …
The disruptive relationship among circadian rhythms, pain, and opioids
JR Bumgarner, EW McCray, RJ Nelson - Frontiers in Neuroscience, 2023 - frontiersin.org
Pain behavior and the systems that mediate opioid analgesia and opioid reward processing
display circadian rhythms. Moreover, the pain system and opioid processing systems …
display circadian rhythms. Moreover, the pain system and opioid processing systems …
Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder
Substance use disorders are a debilitating group of psychiatric disorders with a high degree
of comorbidity with major depressive disorder. Sleep and circadian rhythm disturbances are …
of comorbidity with major depressive disorder. Sleep and circadian rhythm disturbances are …
Circadian rhythms as modulators of brain health during development and throughout aging
R Van Drunen, K Eckel-Mahan - Frontiers in Neural Circuits, 2023 - frontiersin.org
The circadian clock plays a prominent role in neurons during development and throughout
aging. This review covers topics pertinent to the role of 24-h rhythms in neuronal …
aging. This review covers topics pertinent to the role of 24-h rhythms in neuronal …
Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder
In brain, the striatum is a heterogenous region involved in reward and goal-directed
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …
Diurnal alterations in gene expression across striatal subregions in psychosis
Background Psychosis is a defining feature of schizophrenia and highly prevalent in bipolar
disorder. Notably, individuals with these illnesses also have major disruptions in sleep and …
disorder. Notably, individuals with these illnesses also have major disruptions in sleep and …
Melatonin attenuates fentanyl-induced behavioral sensitization and circadian rhythm disorders in mice
K Du, Q Shi, X Zhou, L Zhang, H Su, C Zhang… - Physiology & …, 2024 - Elsevier
Melatonin is a neurohormone synthesized by the pineal gland to regulate the circadian
rhythms and has proven to be effective in treating drug addiction and dependence …
rhythms and has proven to be effective in treating drug addiction and dependence …
Disentangling transcriptomic heterogeneity within the human subgenual anterior cingulate cortex
AK Jenkins, MA Shelton, RF Yin, MT Gorczyca… - Cerebral …, 2024 - academic.oup.com
The subgenual anterior cingulate cortex (sgACC) is a critical site for understanding the
neural correlates of affect and emotion. While the activity of the sgACC is functionally …
neural correlates of affect and emotion. While the activity of the sgACC is functionally …