Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-
coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and …

Glioblastoma (GB) is the most lethal brain tumor, and Wingless (Wg)-related integration site
(WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the …

Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop
many biological advantages that allow them to grow and survive in the unique environment …

Background Malignant glioma is an aggressive cancer requiring new therapeutic targets.
MicroRNAs (miRNAs) regulate gene expression post transcriptionally and are implicated in …

Abstract Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-
rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002. AEG-1/MTDH/LYRIC has …

Abstract The Solute Carrier 1A (SLC1A) family includes two major mammalian transport
systems—the alanine serine cysteine transporters (ASCT1-2) and the human glutamate …

Immunoglobulin G4 (IgG4)‐related disease (IgG4‐RD) of the biliary tree and pancreas is
difficult to distinguish from sclerosing cholangitis and biliary/pancreatic malignancies (CA) …

Impairment of astrocytic glutamate transporter (GLT-1; EAAT2) function is associated with
multiple neurodegenerative diseases, including Parkinson's disease (PD) and manganism …