PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …

Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized,
immobile epithelial cells lose tight junctions, associated adherence, and become migratory …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

The global rise in obesity has revitalized a search for genetic and epigenetic factors
underlying the disease. We present a Drosophila model of paternal-diet-induced …

Breast cancers are highly heterogeneous but can be grouped into subtypes based on
several criteria, including level of expression of certain markers. Claudin-low breast cancer …

Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed
with heterochromatin by rearrangement or transposition. When heterochromatin packaging …

Summary Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …

The enzymes catalyzing lysine and arginine methylation of histones are essential for
maintaining transcriptional programs and determining cell fate and identity. Until recently …

Covalent modifications of histones are central to the regulation of chromatin dynamics, and,
therefore, many biological processes involving chromatin, such as replication, repair …

The importance of histone methylation in gene regulation was suggested over 40 years ago.
Yet, the dynamic nature of this histone modification was recognized only recently, with the …