Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Cell replacement therapy represents a promising approach for treating neurodegenerative
diseases. Contrary to the common addition strategy to generate new neurons from glia by …

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …

The regenerative capacity of neurons is limited in the central nervous system (CNS), with
irreversible neuronal loss upon insult. In contrast, microglia exhibit extraordinary capacity for …

Temporal lobe epilepsy (TLE) is a common drug-resistant epilepsy associated with
abundant cell death in the hippocampus. Here, we develop a novel gene therapy-mediated …

Restoring function in chronic stages of spinal cord injury (SCI) has often been met with
failure or reduced efficacy when regenerative strategies are delayed past the acute or sub …

Direct reprogramming of retinal Müller glia is a promising avenue for replacing
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …

Parkinson's disease (PD) is currently the fastest growing disabling neurological disorder
worldwide, with motor and non-motor symptoms being its main clinical manifestations. The …

The central nervous system's limited capacity for regeneration often leads to permanent
neuronal loss following injury. Reprogramming resident reactive astrocytes into induced …