Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Biocatalytic oxidation reactions: a chemist's perspective

JJ Dong, E Fernández‐Fueyo… - Angewandte Chemie …, 2018 - Wiley Online Library
Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

Scalable biocatalytic C–H oxyfunctionalization reactions

S Chakrabarty, Y Wang, JC Perkins… - Chemical Society …, 2020 - pubs.rsc.org
Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …

Hemoprotein catalyzed oxygenations: P450s, UPOs, and progress toward scalable reactions

G Grogan - JACS Au, 2021 - ACS Publications
The selective oxygenation of nonactivated carbon atoms is an ongoing synthetic challenge,
and biocatalysts, particularly hemoprotein oxygenases, continue to be investigated for their …

Computer-aided tunnel engineering: a promising strategy for improving lipase applications in esterification reactions

W Chong, Y Qi, L Ji, Z Zhang, Z Lu, B Nian, Y Hu - ACS Catalysis, 2023 - ACS Publications
Esterification is one of the most important reactions in organic synthesis and industrial
applications. The applications of lipases in esterification are increasingly widespread and …

The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s

S Meng, Y Ji, LL Zhu, GV Dhoke, MD Davari… - Biotechnology …, 2022 - Elsevier
Cytochrome P450s are heme-thiolate enzymes that have been broadly applied in
pharmaceutical and biosynthesis because of their efficient oxidation at inert carbons …

Biokatalytische Oxidationsreaktionen–aus der Sicht eines Chemikers

JJ Dong, E Fernández‐Fueyo, F Hollmann… - Angewandte …, 2018 - Wiley Online Library
Enzyme gewinnen immer mehr Bedeutung als Katalysatoren für organische
Oxidationsreaktionen. Mit Oxidoreduktasen stehen dem Chemiker vielseitige Werkzeuge für …

Choose Your Own Adventure: A Comprehensive Database of Reactions Catalyzed by Cytochrome P450 BM3 Variants

DJ Fansher, JN Besna, A Fendri, JN Pelletier - ACS catalysis, 2024 - ACS Publications
Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …

MicroGelzymes: pH-independent immobilization of cytochrome P450 BM3 in microgels

M Nöth, L Hussmann, T Belthle, I El-Awaad… - …, 2020 - ACS Publications
Microgels are an emerging class of “ideal” enzyme carriers because of their chemical and
process stability, biocompatibility, and high enzyme loading capability. In this work, we …

Engineering metalloprotein functions in designed and native scaffolds

F Nastri, D D'Alonzo, L Leone, G Zambrano… - Trends in biochemical …, 2019 - cell.com
Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins
makes metalloproteins able to accomplish key processes in biological systems, often very …