Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach
Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …
cAMP response element-binding protein (CREB): a possible signaling molecule link in the pathophysiology of schizophrenia
H Wang, J Xu, P Lazarovici, R Quirion… - Frontiers in molecular …, 2018 - frontiersin.org
Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The
dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is …
dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is …
Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity
Microbiota in the gut affect brain physiology via various pathways, and dysbiosis seems to
play a role in the pathogenesis of Parkinson's disease (PD). Probiotics showed pleiotropic …
play a role in the pathogenesis of Parkinson's disease (PD). Probiotics showed pleiotropic …
Ginsenoside and its therapeutic potential for cognitive impairment
H Feng, M Xue, H Deng, S Cheng, Y Hu, C Zhou - Biomolecules, 2022 - mdpi.com
Cognitive impairment (CI) is one of the major clinical features of many neurodegenerative
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …
[HTML][HTML] Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1/2/CREB/BCL-2 signaling pathway in vitro and in vivo
Ischemic stroke is characterized by the presence of both brain ischemic and reperfusion-
induced injuries in the brain, leading to neuronal dysfunction and death. Artemisinin, an FDA …
induced injuries in the brain, leading to neuronal dysfunction and death. Artemisinin, an FDA …
Metabolomic profiling and neuroprotective effects of purslane seeds extract against acrylamide toxicity in rat's brain
Aim Acrylamide (ACR) is an environmental pollutant with well-demonstrated neurotoxic and
neurodegenerative effects in both humans and experimental animals. The present study …
neurodegenerative effects in both humans and experimental animals. The present study …
[HTML][HTML] CREB: A multifaceted transcriptional regulator of neural and immune function in CNS tumors
Cancers of the central nervous system (CNS) are unique with respect to their tumor
microenvironment. Such a status is due to immune-privilege and the cellular behaviors …
microenvironment. Such a status is due to immune-privilege and the cellular behaviors …
CREB: a multifaceted target for Alzheimer's disease
Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …
The potential of glucose treatment to reduce reactive oxygen species production and apoptosis of inflamed neural cells in vitro
JH Cherng, SJ Chang, HD Tsai, CF Chun, GY Fan… - Biomedicines, 2023 - mdpi.com
Neuroinflammation is a key feature in the pathogenesis of entrapment neuropathies. Clinical
trial evidence suggests that perineural injection of glucose in water at entrapment sites has …
trial evidence suggests that perineural injection of glucose in water at entrapment sites has …
Ion channel drugs suppress cancer phenotype in NG108-15 and U87 cells: toward novel electroceuticals for glioblastoma
Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …