Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

[HTML][HTML] Nosocomial infections in sickle cell anemia patients: Prevention through multi-disciplinary approach: A review

EI Obeagu, GU Obeagu, CA Akinleye, MC Igwe - Medicine, 2023 - journals.lww.com
Sickle cell anemia (SCA), a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, poses a unique set of challenges for both patients and healthcare …

Clinical outcomes of COVID-19 in patients with sickle cell disease and sickle cell trait: A critical appraisal of the literature

WS Hoogenboom, TT Alamuri, DM McMahon… - Blood reviews, 2022 - Elsevier
Individuals with sickle cell disease (SCD) and sickle cell trait (SCT) have many risk factors
that could make them more susceptible to COVID-19 critical illness and death compared to …

A review of the relationship between the immune response, inflammation, oxidative stress, and the pathogenesis of sickle cell anaemia

FI Aboderin, T Oduola, GM Davison, OO Oguntibeju - Biomedicines, 2023 - mdpi.com
Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …

Basic mechanisms of hemolysis-associated thrombo-inflammation and immune dysregulation

JD Dimitrov, LT Roumenina, G Perrella… - … , and Vascular Biology, 2023 - Am Heart Assoc
Independent of etiology, hemolytic diseases are associated with thrombosis, inflammation
and immune dysregulation, all together contributing to organ damage and poor outcome …

Respiratory management of acute chest syndrome in children with sickle cell disease

B Ahmed, M Arigliani, A Gupta - European Respiratory …, 2024 - publications.ersnet.org
Acute chest syndrome (ACS) is a leading cause of respiratory distress and hospitalisation in
children with sickle cell disease (SCD). The aetiology is multifactorial and includes fat …

[PDF][PDF] Men's Essential roles in the Management of Sickle Cell Anemia

EI Obeagu, GU Obeagu, MC Igwe… - … Journal of Scientific …, 2023 - researchgate.net
Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, leading to the deformation of red blood cells and subsequent health …

Exploring the link between maternal hematological disorders during pregnancy and neurological development in newborns: mixed cohort study

E Bakhsh, M Alkhaldi, M Shaban - Life, 2023 - mdpi.com
Maternal hematological disorders during pregnancy may pose a risk to the neurological
development of newborns. To investigate the association between maternal hematological …

Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia

F Vallelian, RM Buzzi, M Pfefferlé… - Cell Death & …, 2022 - nature.com
Heme is an erythrocyte-derived toxin that drives disease progression in hemolytic anemias,
such as sickle cell disease. During hemolysis, specialized bone marrow-derived …

Red blood cells as therapeutic target to treat sickle cell disease

S Bhatt, DA Argueta, K Gupta… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Sickle cell disease (SCD) is the most common inherited diathesis affecting
mostly underserved populations globally. SCD is characterized by chronic pain and fatigue …