Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

T cell-based adoptive immunotherapy has been shown to be a promising treatment for
various types of cancer. However, adoptive T cell therapy currently requires the custom …

Not all adaptive immune systems use the immunoglobulin fold as the basis for specific
recognition molecules: sea lampreys, for example, have evolved an adaptive immune …

A major challenge in adoptive T cell immunotherapy is the discovery of natural T cell
receptors (TCRs) with high activity and specificity to tumor antigens. Engineering synthetic …

Adoptive T cell therapies have achieved significant clinical responses, especially in
hematopoietic cancers. Two types of receptor systems have been used to redirect the activity …

The described protocols enable thorough screening of polypeptide libraries with high
confidence in the isolation of improved clones. It should be emphasized that the protocols …

In a cell-surface engineering system established using the yeast Saccharomyces cerevisiae,
novel, so-called arming yeasts are constructed that are armed with biocatalysts in the form of …

T cell receptors (TCRs) exhibit genetic and structural diversity similar to antibodies, but they
have binding affinities that are several orders of magnitude lower. It has been suggested that …

Recognition of molecular diversity of cell surface proteomes in disease is essential for the
development of targeted therapies. Progress in targeted therapeutics requires establishing …

Proteins are increasingly used in basic and applied biomedical research. Many proteins,
however, are only marginally stable and can be expressed in limited amounts, thus …