Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Stat6 is known to drive macrophage M2 polarization. However, how macrophage
polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …

Chronic innate immune signaling in hematopoietic cells is widely described in
myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly …

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates
with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 …

The breakdown of toll-like receptor (TLR) tolerance results in tissue damage, and
hyperactivation of the TLRs and subsequent inflammatory consequences have been …

Background Previous studies have confirmed that the bacterium Treponema pallidum (TP)
or its proteins provide signals to macrophages that induce an inflammatory response; …