Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …

Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …

Highlights•CLRs play an essential role in immunity to fungi and mycobacteria.•CLRs are
involved in the regulation of homeostasis, autoimmunity and allergy.•CLRs recognise and …

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …