The platelet lifeline to cancer: challenges and opportunities
M Haemmerle, RL Stone, DG Menter… - Cancer cell, 2018 - cell.com
Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …
evidence has highlighted platelets as active players in all steps of tumorigenesis including …
Lymph node stromal cells: cartographers of the immune system
AT Krishnamurty, SJ Turley - Nature immunology, 2020 - nature.com
Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …
How leukocytes cross the vascular endothelium
D Vestweber - Nature Reviews Immunology, 2015 - nature.com
Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …
Sphingolipid metabolites in inflammatory disease
M Maceyka, S Spiegel - Nature, 2014 - nature.com
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …
however, growing evidence suggests that they are also significantly involved in cancer, the …
New concepts and mechanisms of platelet activation signaling
Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …
lipid mediator that regulates many processes in vertebrate development, physiology, and …
[HTML][HTML] C-type lectins in immunity: recent developments
IM Dambuza, GD Brown - Current opinion in immunology, 2015 - Elsevier
Highlights•CLRs play an essential role in immunity to fungi and mycobacteria.•CLRs are
involved in the regulation of homeostasis, autoimmunity and allergy.•CLRs recognise and …
involved in the regulation of homeostasis, autoimmunity and allergy.•CLRs recognise and …
High endothelial venules (HEVs) in immunity, inflammation and cancer
L Blanchard, JP Girard - Angiogenesis, 2021 - Springer
High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …