Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Neutrophils: a subgroup of neglected immune cells in ALS

W Cao, D Fan - Frontiers in Immunology, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease
characterized by the loss of motor neurons. Dysregulated peripheral immunity has been …

[HTML][HTML] Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy

C Chu, X Wang, C Yang, F Chen, L Shi, W Xu, K Wang… - Redox Biology, 2023 - Elsevier
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a
primary catalyst for microcirculation dysfunction and enterogenous infection. Previous …

Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease

S Ariño, B Aguilar-Bravo, M Coll, WY Lee… - Journal of …, 2023 - Elsevier
Background & Aims Ductular reaction expansion is associated with poor prognosis in
patients with advanced liver disease. However, the mechanisms promoting biliary cell …

Neutrophils Are Associated with Higher Risk of Incident Amyotrophic Lateral Sclerosis in a BMI‐and Age‐Dependent Manner

W Cao, Z Cao, Y Tian, L Zhang, W Wang… - Annals of …, 2023 - Wiley Online Library
Objective Peripheral immune markers have been associated with the progression and
prognosis of amyotrophic lateral sclerosis (ALS). However, whether dysregulation of …

[HTML][HTML] Efferocytosis in liver disease

H Shi, MP Moore, X Wang, I Tabas - JHEP Reports, 2024 - Elsevier
The process of dead cell clearance by phagocytic cells, called efferocytosis, prevents
inflammatory cell necrosis and promotes resolution and repair. Defective efferocytosis …

[HTML][HTML] The role of neutrophils in alcohol-related hepatitis

RS Khan, PF Lalor, M Thursz, PN Newsome - Journal of Hepatology, 2023 - Elsevier
Alcohol-related liver disease is a major cause of liver disease-associated mortality, with
inpatient care being a major contributor to its clinical and economic burden. Alcohol-related …

Management of alcoholic hepatitis: A clinical perspective

P Kasper, S Lang, HM Steffen, M Demir - Liver International, 2023 - Wiley Online Library
Alcohol‐associated liver disease is the primary cause of liver‐related mortality worldwide
and one of the most common indications for liver transplantation. Alcoholic hepatitis …

[HTML][HTML] Unraveling the complex interplay between epigenetics and immunity in alcohol-associated liver disease: A comprehensive review

Y Liu, T Liu, F Zhang, Y Gao - International Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The mechanisms of immune dysfunction in alcohol-associated liver disease (ALD) have
garnered growing research interest in recent times. Alcohol-mediated immune dysfunction …

Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease …

W Rungratanawanich, JW Ballway, X Wang… - Pharmacology & …, 2023 - Elsevier
Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …