In recent years, the population of neurons in the ventral tegmental area (VTA) and substantia
nigra (SN) has been examined at multiple levels. The results indicate that the projections …

Synapses are the basic units for information processing and storage in the nervous system.
It is only when the synaptic connection is established, that it becomes meaningful to discuss …

A scalable and high-throughput method to identify precise subcellular localization of
endogenous proteins is essential for integrative understanding of a cell at the molecular …

Chemical synapses are the major sites of communication between neurons in the nervous
system and mediate either excitatory or inhibitory signaling. At excitatory synapses …

In the nervous system, only one type of neuron–glial synapse is known to exist: that between
neurons and oligodendrocyte precursor cells (OPCs), yet their composition, assembly …

The lifetime of proteins in synapses is important for their signaling, maintenance, and
remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an …

Despite the constant advances in fluorescence imaging techniques, monitoring endogenous
proteins still constitutes a major challenge in particular when considering dynamics studies …

INTRODUCTION Animal behavior is mediated by molecular, cellular, and circuit
components of the brain. However, because many proteins are broadly expressed, it has …

Defining the structural and functional changes in the nervous system underlying learning
and memory represents a major challenge for modern neuroscience. Although changes in …

Dendritic spines are mushroom-shaped postsynaptic compartments that host biochemical
signal cascades important for synaptic plasticity and, ultimately, learning and memory …