The monocrotaline model of pulmonary hypertension in perspective

JG Gomez-Arroyo, L Farkas… - … of Physiology-Lung …, 2012 - journals.physiology.org
Severe forms of pulmonary arterial hypertension (PAH) are characterized by various
degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary …

Genotoxicity of pyrrolizidine alkaloids

T Chen, N Mei, PP Fu - Journal of Applied Toxicology: An …, 2010 - Wiley Online Library
Pyrrolizidine alkaloids (PAs) are common constituents of many plant species around the
world. PA‐containing plants are probably the most common poisonous plants affecting …

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

Y He, L Zhu, J Ma, G Lin - Archives of toxicology, 2021 - Springer
Pyrrolizidine alkaloids (PAs) and PA N-oxides are common phytotoxins produced by over
6000 plant species. Humans are frequently exposed to PAs via ingestion of PA-containing …

Alkaloids in food: a review of toxicity, analytical methods, occurrence and risk assessments

AJ Akinboye, K Kim, S Choi, I Yang, JG Lee - Food Science and …, 2023 - Springer
Alkaloids have been utilized by humans for years. They have diverse applications in
pharmaceuticals. They have been proven to be effective in treating a number of diseases …

[HTML][HTML] Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from …

S Mohotti, S Rajendran, T Muhammad… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Sri Lanka is known to have very diverse flora.
Many of these species are used for plant-based remedies, which form the integral part of two …

Simultaneous extraction and separation of flavonoids and alkaloids from Crotalaria sessiliflora L. by microwave-assisted cloud-point extraction

X Tang, D Zhu, W Huai, W Zhang, C Fu, X Xie… - Separation and …, 2017 - Elsevier
A novel method of simultaneous extraction and separation of flavonoids and alkaloids from
Crotalaria sessiliflora L., was developed by microwave-assisted cloud-point extraction …

Scientific opinion on pyrrolizidine alkaloids in food and feed

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2011 - Wiley Online Library
Abstract The European Food Safety Authority (EFSA) was asked by the European
Commission to deliver a scientific opinion on pyrrolizidine alkaloids (PA) in food and feed …

[HTML][HTML] The potential role of physical exercise in the treatment of epilepsy

RM Arida, FA Scorza, SG da Silva, SC Schachter… - Epilepsy & Behavior, 2010 - Elsevier
The beneficial effects of exercise for people with epilepsy, including reduction of seizure
susceptibility, improvement of quality of life, reduction of anxiety and depression, and better …

The use of plants containing genotoxic carcinogens as foods and medicine

G Prinsloo, N Nogemane, R Street - Food and Chemical Toxicology, 2018 - Elsevier
In many developing countries, populations rely on traditional medicine for primary health
care, which have infiltrated commercial markets globally as natural remedies are generally …

Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline

W Zhuang, G Lian, B Huang, A Du… - Experimental …, 2018 - journals.sagepub.com
Pulmonary arterial hypertension (PAH) in humans manifests as a chronic process. However,
PAH induced by high-dose monocrotaline (MCT) in animals occurs as a subacute process …