For over a century, frogs have been studied across various scientific fields, including
physiology, embryology, neuroscience,(neuro) endocrinology, ecology, genetics …

The expression of multiple connexin (Cx) types in the epidermis, their differential expression
during wound closure and the association of skin pathology with specific Cx gene mutations …

Mutations in GJB2 (connexin [Cx] 26) cause either deafness or deafness associated with
skin diseases. That different disorders can be caused by distinct mutations within the same …

Mutations in human connexin (Cx) genes have been related to diseases, which we termed
connexinopathies. Such hereditary disorders include nonsyndromic or syndromic deafness …

Gap junction proteins (connexins) are differentially expressed throughout the multiple layers
of the epidermis. A variety of skin conditions arise with aberrant connexin expression or …

Porokeratotic eccrine ostial and dermal duct nevus, or porokeratotic eccrine nevus (PEN), is
a hyperkeratotic epidermal nevus. Several cases of widespread involvement have been …

Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This
tissue is also highly accessible for therapeutic targeting. This review highlights the role of …

The keratitis-ichthyosis-deafness (KID) syndrome is characterized by corneal, skin, and
hearing abnormalities. KID has been linked to heterozygous dominant missense mutations …

One of the most common forms of genetic deafness has been predominantly associated with
pathogenic variants in the GJB2 gene, encoding transmembrane protein connexin 26 …

The GJB2 gene is located on chromosome 13q12 and it encodes the connexin 26, a
transmembrane protein involved in cell-cell attachment of almost all tissues. GJB2 mutations …