The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

In clinical therapy of evolving acute myocardial infarction, coronary reperfusion has proven
to be the only way to limit infarct size, provided it occurs soon enough after coronary artery …

Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Gap junctions form the cell-to-cell pathways for propagation of the precisely orchestrated
patterns of current flow that govern the regular rhythm of the healthy heart. As in most tissues …

Excess generation of reactive oxygen species (ROS) and cytosolic calcium accumulation
play major roles in the initiation of programmed cell death during acute myocardial …

As of yet, only a few strategies to prevent myocardial reperfusion injury have been tested
clinically. In the first minutes of reperfusion, the myocardium can be damaged by contracture …

Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated
insulin resistance. Yet, the coordinated tissue response to ERS remains unclear. Increased …

During the past decade, the understanding has grown that control of the conditions of
reperfusion is critical for salvaging ischemic–reperfused myocardium. The first few minutes …