Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury

YT Song, PC Liu, J Tan, CY Zou, QJ Li, J Li-Ling… - Stem Cell Research & …, 2021 - Springer
Intrauterine adhesion refers to endometrial repair disorders which are usually caused by
uterine injury and may lead to a series of complications such as abnormal menstrual …

Stem cell characteristics and the therapeutic potential of amniotic epithelial cells

T Miki - American Journal of Reproductive Immunology, 2018 - Wiley Online Library
Multiple stem cell types can be isolated from the human placenta. Recent advances in stem
cell biology have revealed that human amniotic epithelial cells (hAEC s) are one of the …

Amnion epithelial cell-derived exosomes restrict lung injury and enhance endogenous lung repair

JL Tan, SN Lau, B Leaw, HPT Nguyen… - Stem cells …, 2018 - academic.oup.com
Idiopathic pulmonary fibrosis (IPF) is characterized by chronic inflammation, severe scarring,
and stem cell senescence. Stem cell-based therapies modulate inflammatory and fibrogenic …

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal …

E Ragni, A Papait, C Perucca Orfei… - Stem Cells …, 2021 - academic.oup.com
Human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) are easily
obtained in large quantities and free from ethical concerns. Promising therapeutic results for …

The immunomodulatory properties of amniotic cells: the two sides of the coin

M Magatti, E Vertua, A Cargnoni, A Silini… - Cell …, 2018 - journals.sagepub.com
Among the many cell types useful in developing therapeutic treatments, human amniotic
cells from placenta have been proposed as valid candidates. Both human amniotic epithelial …

Amniotic membrane mesenchymal cells-derived factors skew T cell polarization toward Treg and downregulate Th1 and Th17 cells subsets

S Pianta, P Bonassi Signoroni, I Muradore… - Stem Cell Reviews and …, 2015 - Springer
We previously demonstrated that cells derived from the mesenchymal layer of the human
amniotic membrane (hAMSC) and their conditioned medium (CM-hAMSC) modulate …

Hepatocyte growth factor is required for mesenchymal stromal cell protection against bleomycin-induced pulmonary fibrosis

EF Cahill, H Kennelly, F Carty… - Stem cells …, 2016 - academic.oup.com
The incidence of idiopathic pulmonary fibrosis is on the rise and existing treatments have
failed to halt or reverse disease progression. Mesenchymal stromal cells (MSCs) have …

Immunomodulatory properties of human placental mesenchymal stem/stromal cells

MH Abumaree, FM Abomaray, MA Alshabibi… - Placenta, 2017 - Elsevier
Mesenchymal stem/stromal cells (MSCs) are isolated from various fetal and adult tissues
such as bone marrow, adipose tissue, cord blood and placenta. Placental MSCs (pMSCs) …

Human amnion favours tissue repair by inducing the M1‐to‐M2 switch and enhancing M2 macrophage features

M Magatti, E Vertua, S De Munari… - Journal of tissue …, 2017 - Wiley Online Library
Human amniotic mesenchymal cells (hAMTCs) possess interesting immunomodulatory
properties, making them attractive candidates for regenerative medicine applications …

Comparison of EV-free fraction, EVs, and total secretome of amniotic mesenchymal stromal cells for their immunomodulatory potential: A translational perspective

A Papait, E Ragni, A Cargnoni, E Vertua… - Frontiers in …, 2022 - frontiersin.org
Amniotic mesenchymal stromal cells (hAMSCs) have unique immunomodulatory properties
demonstrated in vitro and in vivo in various diseases in which the dysregulated immune …