Genetics of congenital heart disease
K Williams, J Carson, C Lo - Biomolecules, 2019 - mdpi.com
Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
[HTML][HTML] A transcription factor atlas of directed differentiation
Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …
processes and cell states. To comprehensively understand TFs and the programs they …
A patterned human primitive heart organoid model generated by pluripotent stem cell self-organization
Pluripotent stem cell-derived organoids can recapitulate significant features of organ
development in vitro. We hypothesized that creating human heart organoids by mimicking …
development in vitro. We hypothesized that creating human heart organoids by mimicking …
In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
J Lee, A Sutani, R Kaneko, J Takeuchi… - Nature …, 2020 - nature.com
Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the
difficulties in modeling this complex organ currently by in vitro models. Here we develop a …
difficulties in modeling this complex organ currently by in vitro models. Here we develop a …
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a
powerful tool for human disease modeling and therapeutic testing. However, their use …
powerful tool for human disease modeling and therapeutic testing. However, their use …
Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology
HD Devalla, V Schwach, JW Ford, JT Milnes… - EMBO molecular …, 2015 - embopress.org
Drugs targeting atrial‐specific ion channels, Kv1. 5 or Kir3. 1/3.4, are being developed as
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried …
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried …
Atrial-like engineered heart tissue: an in vitro model of the human atrium
M Lemme, BM Ulmer, MD Lemoine, ATL Zech… - Stem cell reports, 2018 - cell.com
Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs) are
under investigation for their suitability as human models in preclinical drug development …
under investigation for their suitability as human models in preclinical drug development …
[HTML][HTML] Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation
Effective drugs for atrial fibrillation (AF) are lacking, resulting in significant morbidity and
mortality. This study demonstrates that network proximity analysis of differentially expressed …
mortality. This study demonstrates that network proximity analysis of differentially expressed …
Impaired human cardiac cell development due to NOTCH1 deficiency
Background: NOTCH1 pathogenic variants are implicated in multiple types of congenital
heart defects including hypoplastic left heart syndrome, where the left ventricle is …
heart defects including hypoplastic left heart syndrome, where the left ventricle is …