Angiotensin-converting enzyme (ACE) is a zinc-dependent peptidase responsible for
converting angiotensin I into the vasoconstrictor angiotensin II. However, ACE is a relatively …

Hypertension is a prevalent condition worldwide and is the key risk factor for fatal
cardiovascular complications, such as stroke, sudden cardiac death and heart failure …

Importance of the field: The renin-angiotensin system (RAS) is nowadays an important target
in cardiovascular diseases and we are currently on the verge of a new interpretation of its …

Over the last decades, heart failure with preserved ejection fraction (HFpEF) has received
less attention by the medical and scientific communities, which led to the emergence of a …

Angiotensin II (Ang II) is critical in myocardial pathogenesis, mostly via stimulating NADPH
oxidase. Neuronal nitric oxide synthase (nNOS) has recently been shown to play important …

Although systole was for long considered the core of cardiac function, hemodynamic
performance is evenly dependent on appropriate systolic and diastolic functions. The …

Background Although the angiotensin receptor-neprilysin inhibitor (ARNI)
sacubitril/valsartan started a new era in heart failure (HF) treatment, less is known about the …

G protein-coupled receptors (GPCRs) are a virtually ubiquitous class of membrane-bound
receptors, which functionally couple hormone or neurotransmitter signals to physiological …

Durante las últimas décadas, la insuficiencia cardíaca con fracción de eyección preservada
(ICFEP) fue blanco de menor atención por parte de las comunidades médica y científica, lo …

Aims The present study investigates the expression and clinical relevance of the constitutive
NO synthases in heart and peripheral blood mononuclear cells (PBMCs) obtained from …