The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

There are many challenges in the field of public health sciences. Rational decisions are
required in order to treat different diseases, gain knowledge and wealth regarding research …

The neddylation pathway belongs post-translational modifications and plays important roles
in regulating viral infection and replication. To address the relationship of influenza A virus …

Background Targeted therapy is a novel, promising approach to anticancer treatment that
endeavors to overcome drug resistance to traditional chemotherapies. Patients with the …

The catalytic efficiency and unrivaled selectivity with which enzymes convert substrates to
products have been tapped for widespread chemical transformations within biomedical …

Melanoma is one of the most aggressive skin cancers with fiercely increasing incidence and
mortality. Since the progressive understanding of the mutational landscape and …

Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major
cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug …

Simple Summary BRF2, a subunit of the RNA polymerase III transcription complex, is
upregulated in a wide variety of cancers and is a potential therapeutic target; however, no …

MurI is one of the most significant role players in the biosynthesis of the peptidoglycan layer
in Neisseria gonorrhoeae (Ng). We attempted to highlight the structural and functional …

Drug discovery and the development of safe and effective therapeutics is an intricate
procedure, further complicated in the context of cancer research by the inherent …