The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

Intracellular energy distribution has attracted much interest and has been proposed to occur
in skeletal muscle via metabolite-facilitated diffusion,; however, genetic evidence suggests …

Calcium is believed to regulate mitochondrial oxidative phosphorylation, thereby
contributing to the maintenance of cellular energy homeostasis. Skeletal muscle, with an …

Human disease pathophysiology commonly involves metabolic disruption at both the
cellular and subcellular levels. Isolated mitochondria are a powerful model for separating …

Mapping biological circuit connectivity has revolutionized our understanding of structure-
function relationships. Although connectomic analyses have primarily focused on neural …

Chronic metabolic diseases have been linked to molecular signatures of mitochondrial
dysfunction. Nonetheless, molecular remodeling of the transcriptome, proteome, and/or …

Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers
according to their contractile and metabolic properties. Here, we developed a high …

In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers
designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers …

Mitochondria are the primary source of energy production and are implicated in a wide
range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on …