Toward precision medicine: circadian rhythm of blood pressure and chronotherapy for hypertension-2021 NHLBI workshop report

ML Gumz, D Shimbo, M Abdalla, RC Balijepalli… - …, 2023 - Am Heart Assoc
Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood
pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of …

The role of artificial intelligence in the treatment of obstructive sleep apnea

HL Brennan, SD Kirby - Journal of Otolaryngology-Head & …, 2023 - journals.sagepub.com
Background The first-line and most common treatment for obstructive sleep apnea is nasal
continuous positive airway pressure, which serves as a pneumatic splint to stabilize the …

Circadian clock disruptions link oxidative stress and systemic inflammation to metabolic syndrome in obstructive sleep apnea patients

X Li, X Liu, Q Meng, X Wu, X Bing, N Guo… - Frontiers in …, 2022 - frontiersin.org
Objectives: Obstructive sleep apnea (OSA) is an independent risk factor for metabolic
syndrome (MetS). Recent studies have indicated that circadian clock genes were …

Designing and Developing a Vision-Based System to Investigate the Emotional Effects of News on Short Sleep at Noon: An Experimental Case Study

AJ Moshayedi, NMI Uddin, AS Khan, J Zhu… - Sensors, 2023 - mdpi.com
Background: Sleep is a critical factor in maintaining good health, and its impact on various
diseases has been recognized by scientists. Understanding sleep patterns and quality is …

Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression

BSC Koritala, YY Lee, LS Gaspar, SS Bhadri, W Su… - Plos …, 2023 - journals.plos.org
Intermittent hypoxia (IH) is a major clinical feature of obstructive sleep apnea (OSA). The
mechanisms that become dysregulated after periods of exposure to IH are unclear …

Is obstructive sleep apnea a circadian rhythm disorder?

J Šmon, E Kočar, T Pintar… - Journal of sleep …, 2023 - Wiley Online Library
Obstructive sleep apnea is the most common sleep‐related breathing disorder worldwide
and remains underdiagnosed. Its multiple associated comorbidities contribute to a …

Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients

A Gabryelska, S Turkiewicz, P Kaczmarski… - Translational …, 2024 - nature.com
Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders.
Our study aims to investigate the association of circadian clock gene expressions, and the …

Circadian biology in obstructive sleep apnea

BSC Koritala, Z Conroy, DF Smith - Diagnostics, 2021 - mdpi.com
Obstructive sleep apnea (OSA) is a complex process that can lead to the dysregulation of
the molecular clock, as well as 24 h rhythms of sleep and wake, blood pressure, and other …

Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients

Z Wei, H Shen, F Wang, W Huang, X Li, H Xu… - Annals of …, 2024 - Taylor & Francis
Background Intestinal barrier dysfunction and systemic inflammation are common in
obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti …

Changes in cortisol levels by continuous positive airway pressure in patients with obstructive sleep apnoea: Meta‐analysis of 637 individuals

G Ken‐Dror, CH Fry, P Murray, D Fluck… - Clinical …, 2021 - Wiley Online Library
Background Obesity, obstructive sleep apnoea (OSA) and hypertension frequently coexist
and are associated with elevated cortisol levels. Identification and treatment of such patients …