This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We
describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the …

Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

As neonatal sepsis is a severe condition, there is a call for reliable biomarkers to
differentiate between infected and noninfected newborns. Although blood culture has been …

Neutrophilic granulocytes express Fcγ receptor (FcγR)[cluster of differentiation 64 (CD64)
antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry …

OBJECTIVE: We performed a systematic review and meta-analysis of studies to evaluate the
diagnostic accuracy of expression of CD64 on polymorphonuclear neutrophils (PMN) as a …

BACKGROUND: Neutrophil CD64 expression is widely reported as an efficacious biomarker
to differentiate infected patients from other non-infected patients. This meta-analysis was …

Sepsis, an innate immunological response of systemic inflammation to infection, is a
growing problem worldwide with a relatively high mortality rate. Immediate treatment is …

Objective To compare the diagnostic accuracy of neutrophil and monocyte CD64 indexes
(CD64in and CD64im) for sepsis in critically ill neonates and children with that of …

The rapid diagnosis and management of bacterial infection are heavily dependent upon
clinical assessment. Blood culture may take up to 2 days for results and may be suspect …