Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …

Human cytomegalovirus (HCMV) infects individuals of all ages and establishes a lifelong
latency. Current antiviral drugs are suboptimal in efficacy and safety and ineffective against …

Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1, 6] naphthyridines
(ie, L-870,810) were one of the promising class of antiretroviral drugs developed by Merck …

This review presents a systematic survey of the literature (through the end of 2014) for de
novo syntheses of 3-pyrrolin-2-ones from acyclic precursors or via transformation of other …

Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design
of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and …

Human cytomegalovirus (HCMV) replication requires a metal‐dependent endonuclease at
the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have …

In recent years, HIV‐1 integrase (IN) has become an attractive target for designing
antiretroviral agents. The first IN inhibitor approved for clinical use, raltegravir, has validated …

Background Herpes simplex virus type-1 (HSV-1) is the primary cause of facial lesions
(mouth, lips, and eyes) in humans. The widespread use of acyclovir and nucleoside …

HIV-1 integrase is an extremely important nominee in developing new and effective drugs
especially naphthyridine compounds against acquired immune deficiency syndrome. The …

The existence of preferred molecular scaffolds that possess inherent biological activity,
called privileged structures, is now well recognized. Such privileged structures not only …