Thioredoxin reductase inhibition for cancer therapy
R Gencheva, ESJ Arnér - Annual Review of Pharmacology and …, 2022 - annualreviews.org
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
[HTML][HTML] Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
M Deponte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …
challenges encountered by all life forms. In the course of evolution, nature optimized …
A novel persulfide detection method reveals protein persulfide-and polysulfide-reducing functions of thioredoxin and glutathione systems
É Dóka, I Pader, A Bíró, K Johansson, Q Cheng… - Science …, 2016 - science.org
Hydrogen sulfide signaling involves persulfide formation at specific protein Cys residues.
However, overcoming current methodological challenges in persulfide detection and …
However, overcoming current methodological challenges in persulfide detection and …
[HTML][HTML] Glutaredoxin: Discovery, redox defense and much more
Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …
Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance
The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
Thioredoxin and thioredoxin reductase: current research with special reference to human disease
A Holmgren, J Lu - Biochemical and biophysical research communications, 2010 - Elsevier
Thioredoxin (Trx) and thioredoxin reductase (TrxR) plus NADPH, comprising the thioredoxin
system, has a large number of functions in DNA synthesis, defense against oxidative stress …
system, has a large number of functions in DNA synthesis, defense against oxidative stress …
The human selenoproteome: recent insights into functions and regulation
MA Reeves, PR Hoffmann - Cellular and molecular life sciences, 2009 - Springer
Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …
ATM activates the pentose phosphate pathway promoting anti‐oxidant defence and DNA repair
C Cosentino, D Grieco, V Costanzo - The EMBO journal, 2011 - embopress.org
Ataxia telangiectasia (A‐T) is a human disease caused by ATM deficiency characterized
among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and …
among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and …
Thioredoxin reductase as a pharmacological target
Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …
The thioredoxin system as a therapeutic target in human health and disease
DFD Mahmood, A Abderrazak, K El Hadri… - Antioxidants & redox …, 2013 - liebertpub.com
The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …