The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …

Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths.
Even though there is a steady increase in patient survival for most cancers over the …

The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an
irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting …

In pancreatic ductal adenocarcinoma (PDAC), mutant KRAS stimulates the translation
initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits …

Simple Summary Pancreatic cancer has a five-year survival rate of less than 8% and is the
fourth leading cause of cancer death in the United States. Existing therapeutics have failed …

Glioblastoma is the most common lethal malignant intracranial tumor with a low 5‐year
survival rate. Currently, the maximal safe surgical resection, followed by high‐dose …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant disease, which has an
extremely low survival rate of< 9% in the United States. As a new hallmark of cancer …