ContextBecause of population migration from endemic areas and newly instituted blood
bank screening, US clinicians are likely to see an increasing number of patients with …

The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …

Chagas disease, caused by the infection with T rypanosoma cruzi, is endemic in all L atin A
merica. Due to the increase in population migration, C hagas disease has spread worldwide …

CD8+ T cells are crucial for control of a number of medically important protozoan parasites,
including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the …

The aim of this paper is to discuss the main ecological interactions between the parasite
Trypanosoma cruzi and its hosts, the mother and the fetus, leading to the transmission and …

In this study, we document the development of stable, antigen-independent CD8+ T cell
memory after drug-induced cure of a chronic infection. By establishing a system for drug …

Introduction Chagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi)
infection, is a major contributor to heart failure in Latin America. There are significant gaps in …

CD8+ T cells have emerged as crucial players in the control of a number of protozoan
pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent …