Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Responding to the increased popularity of herbal medicines and other forms of
complementary or alternative medicine world-wide, this reference reviews and evaluates …

Brain temperature, as an independent therapeutic target variable, has received increasingly
intense clinical attention. To date, brain hypothermia represents the most potent …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Significant amounts of oxygen free radicals (oxidants) are generated during cerebral
ischemia/reperfusion, and oxidative stress plays an important role in brain damage after …

C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …

Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme
complex with the sole function of producing superoxide anion and reactive oxygen species …

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. In
recent years, reperfusion treatments based on thrombolytic and thrombectomy are major …