For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

This Review emphasizes the impact of APOE4—the most significant genetic risk factor for
Alzheimer's disease (AD)—on peripheral and neural effects starting in childhood. We …

Tauopathies are a collection of neurodegenerative diseases characterized by the
accumulation of pathogenic aggregates of the microtubule‐associated protein tau. Despite …

Repetitive mild traumatic brain injuries (r-mTBI) sustained in the military or contact sports
have been associated with the accumulation of extracellular tau in the brain, which may …

Background and Objectives We previously found that the APOE genotype affects the rate of
cognitive decline in mild-to-moderate Alzheimer disease (AD) dementia independently of its …

Alzheimer's disease (AD) is a neuropathology characterized by progressive cognitive
impairment and dementia. The disease is attributed to senile plaques, which are aggregates …

Coronavirus disease 2019 (COVID-19) was initially considered a primarily respiratory
disease but is now known to affect other organs including the heart and brain. A major route …

The ε4 allele of the apolipoprotein E (APOE4) gene is an established risk factor for
Alzheimer's disease but its impact on cognition in healthy adults across the lifespan is …

Post-stroke depressive disorders (PSD) and post-stroke cognitive impairments (PCI) are
frequent consequences of ischemic stroke (IS). The study was focused on exploring possible …

Tauopathies encompass a collection of chronic, progressive neurodegenerative diseases,
including Alzheimer's disease (AD), chronic traumatic encephalopathy, and corticobasal …