Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature reviews genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

The impact of epitranscriptomic modifications on liver disease

KA Berggren, RE Schwartz, RE Kleiner… - Trends in Endocrinology & …, 2024 - cell.com
RNA modifications have emerged as important mechanisms of gene regulation.
Developmental, metabolic, and cell cycle regulatory processes are all affected by …

Interaction between N6-methyladenosine (m6A) modification and environmental chemical-induced diseases in various organ systems

X Zhu, H Fu, J Sun, Q Xu - Chemico-Biological Interactions, 2023 - Elsevier
A wide variety of chemicals are ubiquitous in the environment and thus exposure to these
environmental chemicals poses a serious threat to public health. Particularly, environmental …

Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model

BJ Petri, KM Piell, B Wahlang, KZ Head… - Environmental …, 2022 - Elsevier
Exposure to high fat diet (HFD) and persistent organic pollutants including polychlorinated
biphenyls (PCBs) is associated with liver injury in human populations and non-alcoholic fatty …

Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease

BJ Petri, KM Piell, B Wahlang, KZ Head… - Environmental …, 2023 - Elsevier
Exposure to polychlorinated biphenyls (PCBs) has been associated with liver injury in
human cohorts and with nonalcoholic steatohepatitis (NASH) in mice fed a high fat diet …

Altered splicing factor and alternative splicing events in a mouse model of diet-and polychlorinated biphenyl-induced liver disease

BJ Petri, KM Piell, B Wahlang, KZ Head… - Environmental …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is associated with human environmental exposure
to polychlorinated biphenyls (PCBs). Alternative splicing (AS) is dysregulated in steatotic …

Emerging roles for DNA 6mA and RNA m6A methylation in mammalian genome

L Xie, X Zhang, J Xie, Y Xu, XJ Li, L Lin - International Journal of …, 2023 - mdpi.com
Epigenetic methylation has been shown to play an important role in transcriptional
regulation and disease pathogenesis. Recent advancements in detection techniques have …

The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol‐associated liver disease

TC Gripshover, B Wahlang, KZ Head… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background The prevalence of alcohol‐associated liver disease (ALD), a subtype of fatty
liver disease (FLD), continues to rise. ALD is a major cause of preventable death …

Metabolic analysis of nucleosides/bases in the urine and serum of patients with alcohol-associated liver disease

L He, V Vatsalya, X Ma, CM Klinge, MC Cave, W Feng… - Metabolites, 2022 - mdpi.com
Accumulating evidence supports the important role of RNA modifications in liver disease
pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have …

Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure

KM Piell, BJ Petri, KZ Head, B Wahlang, R Xu… - Environmental …, 2023 - Elsevier
Chronic environmental exposure to polychlorinated biphenyls (PCBs) is associated with non-
alcoholic fatty liver disease (NAFLD) and exacerbated by a high fat diet (HFD). Here, chronic …