Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
The impact of epitranscriptomic modifications on liver disease
KA Berggren, RE Schwartz, RE Kleiner… - Trends in Endocrinology & …, 2024 - cell.com
RNA modifications have emerged as important mechanisms of gene regulation.
Developmental, metabolic, and cell cycle regulatory processes are all affected by …
Developmental, metabolic, and cell cycle regulatory processes are all affected by …
Interaction between N6-methyladenosine (m6A) modification and environmental chemical-induced diseases in various organ systems
X Zhu, H Fu, J Sun, Q Xu - Chemico-Biological Interactions, 2023 - Elsevier
A wide variety of chemicals are ubiquitous in the environment and thus exposure to these
environmental chemicals poses a serious threat to public health. Particularly, environmental …
environmental chemicals poses a serious threat to public health. Particularly, environmental …
Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model
Exposure to high fat diet (HFD) and persistent organic pollutants including polychlorinated
biphenyls (PCBs) is associated with liver injury in human populations and non-alcoholic fatty …
biphenyls (PCBs) is associated with liver injury in human populations and non-alcoholic fatty …
Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease
Exposure to polychlorinated biphenyls (PCBs) has been associated with liver injury in
human cohorts and with nonalcoholic steatohepatitis (NASH) in mice fed a high fat diet …
human cohorts and with nonalcoholic steatohepatitis (NASH) in mice fed a high fat diet …
Altered splicing factor and alternative splicing events in a mouse model of diet-and polychlorinated biphenyl-induced liver disease
Non-alcoholic fatty liver disease (NAFLD) is associated with human environmental exposure
to polychlorinated biphenyls (PCBs). Alternative splicing (AS) is dysregulated in steatotic …
to polychlorinated biphenyls (PCBs). Alternative splicing (AS) is dysregulated in steatotic …
Emerging roles for DNA 6mA and RNA m6A methylation in mammalian genome
L Xie, X Zhang, J Xie, Y Xu, XJ Li, L Lin - International Journal of …, 2023 - mdpi.com
Epigenetic methylation has been shown to play an important role in transcriptional
regulation and disease pathogenesis. Recent advancements in detection techniques have …
regulation and disease pathogenesis. Recent advancements in detection techniques have …
The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol‐associated liver disease
TC Gripshover, B Wahlang, KZ Head… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background The prevalence of alcohol‐associated liver disease (ALD), a subtype of fatty
liver disease (FLD), continues to rise. ALD is a major cause of preventable death …
liver disease (FLD), continues to rise. ALD is a major cause of preventable death …
Metabolic analysis of nucleosides/bases in the urine and serum of patients with alcohol-associated liver disease
Accumulating evidence supports the important role of RNA modifications in liver disease
pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have …
pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have …
Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure
Chronic environmental exposure to polychlorinated biphenyls (PCBs) is associated with non-
alcoholic fatty liver disease (NAFLD) and exacerbated by a high fat diet (HFD). Here, chronic …
alcoholic fatty liver disease (NAFLD) and exacerbated by a high fat diet (HFD). Here, chronic …