For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

Actin filaments are major components of at least 15 distinct structures in metazoan cells.
These filaments assemble from a common pool of actin monomers, but do so at different …

Cell migration is an essential feature of eukaryotic life, required for processes ranging from
feeding and phagoctyosis to development, healing, and immunity. Migration requires the …

Lamellipodia and ruffles are veil-shaped cell protrusions composed of a highly branched
actin filament meshwork assembled by the Arp2/3 complex. These structures not only …

Cell motility and migration play pivotal roles in numerous physiological and
pathophysiological processes including development and tissue repair. Cell migration is …

The Arp2/3 complex is an actin nucleator that plays a critical role in many cellular processes.
Its activities are regulated by nucleation-promoting factors (NPFs) that function primarily …

Metastasizing tumor cells use matrix metalloproteases, such as the transmembrane
collagenase MT1-MMP, together with actin-based protrusions, to break through extracellular …

Cell migration entails a plethora of activities combining the productive exertion of protrusive
and contractile forces to allow cells to push and squeeze themselves through cell clumps …

Multiple modes of endocytosis require actin-dependent remodeling of the plasma
membrane; however, neither the factors linking these processes nor their mechanisms of …

Actin cytoskeleton remodeling provides the forces required for a variety of cellular processes
based on membrane dynamics, such as endocytosis, exocytosis, and vesicular trafficking at …