Epidermolysis bullosa (EB) is an inherited, heterogeneous group of rare genetic dermatoses
characterized by mucocutaneous fragility and blister formation, inducible by often minimal …

While wound therapy remains a clinical challenge in current medical practice, much effort
has focused on developing biological therapeutic approaches. This paper presents a …

Designer nucleases allow specific and precise genomic modifications and represent
versatile molecular tools for the correction of disease-associated mutations. In this study, we …

With the ability to induce rapid and efficient repair of disease-causing mutations,
CRISPR/Cas9 technology is ideally suited for gene therapy approaches for recessively and …

In orchestrating the wound healing process, the immune system plays a critical role. Hence,
controlling the immune system to repair skin defects is an attractive approach. The highly …

The importance of skin to survival, and the devastating physical and psychological
consequences of scarring following reparative healing of extensive or difficult to heal human …

Junctional epidermolysis bullosa (JEB) is a debilitating hereditary skin disorder caused by
mutations in genes encoding laminin-332, type XVII collagen (C17), and integrin-α6β4 …

End-joining‒based gene editing is frequently used for efficient reframing and knockout of
target genes. However, the associated random, unpredictable, and often heterogeneous …

Genodermatoses are rare inherited skin diseases that frequently affect other organs. They
often have marked effects on wellbeing and may cause early death. Progress in molecular …

The skin provides direct protection to the human body from assault by the harsh external
environment. The crucial function of this organ is significantly disrupted in genodermatoses …