Comment on:'What are the optimal pharmacokinetic/pharmacodynamic targets for beta-lactamase inhibitors? A systematic review'
DJ Bentley - Journal of Antimicrobial Chemotherapy, 2024 - academic.oup.com
Dear Dr Donnelly Assefa et al. are to be commended on their comprehensive review of
pharmacokinetic/pharmacodynamic (PK/PD) targets for β-lactamase inhibitors. 1 Their …
pharmacokinetic/pharmacodynamic (PK/PD) targets for β-lactamase inhibitors. 1 Their …
Cefepime-Enmetazobactam: A Drug Review of a Novel Beta-Lactam/Beta-Lactamase Inhibitor
Objective: To describe and analyze the pharmacodynamic and pharmacokinetic properties
and clinical evidence supporting the efficacy and use of cefepime-enmetazobactam (FEP …
and clinical evidence supporting the efficacy and use of cefepime-enmetazobactam (FEP …
Revisiting the Checkerboard to Inform Development of β-Lactam/β-Lactamase Inhibitor Combinations
DJ Bentley - Antibiotics, 2024 - mdpi.com
A two-dimensional “checkerboard” array employing systematic titration (eg, serial two-fold
dilutions) is a well-established in vitro method for exploring the antibacterial effects of novel …
dilutions) is a well-established in vitro method for exploring the antibacterial effects of novel …
Chemical Methods for Construction of Spirocyclic β-Lactams and their Biological Importance
Spirocyclic β-lactams are a family of natural and synthetic chemicals with different biological
activity, including antibacterial properties and interaction with critical physiological targets …
activity, including antibacterial properties and interaction with critical physiological targets …