The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

High sugar intake has long been recognized as a potential environmental risk factor for
increased incidence of many non-communicable diseases, including obesity, cardiovascular …

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …

Metabolic alterations in the microenvironment significantly modulate tumor
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …

CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …

Nutrient availability is central for T-cell functions and immune responses. Here we report that
CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non …

Regulatory T (Treg) cells are crucial for peripheral immune tolerance and prevention of
autoimmunity and tissue damage. Treg cells are inherently defined by the expression of the …

T cell function and fate can be influenced by several metabolites: in some cases, acting
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …

The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …

Upon activation, naïve CD4+ T helper (Th) cells differentiate into distinct Th effector cell
lineages depending on the local cytokine environment. However, these polarized Th cells …