[HTML][HTML] Redox regulation of the immune response
G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
[HTML][HTML] Excessive intake of sugar: An accomplice of inflammation
X Ma, F Nan, H Liang, P Shu, X Fan, X Song… - Frontiers in …, 2022 - frontiersin.org
High sugar intake has long been recognized as a potential environmental risk factor for
increased incidence of many non-communicable diseases, including obesity, cardiovascular …
increased incidence of many non-communicable diseases, including obesity, cardiovascular …
[HTML][HTML] Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity
Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
J Cheng, J Yan, Y Liu, J Shi, H Wang, H Zhou, Y Zhou… - Cell Metabolism, 2023 - cell.com
Metabolic alterations in the microenvironment significantly modulate tumor
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …
[HTML][HTML] Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells
CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …
[HTML][HTML] Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses
J Wu, G Li, L Li, D Li, Z Dong, P Jiang - Nature cell biology, 2021 - nature.com
Nutrient availability is central for T-cell functions and immune responses. Here we report that
CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non …
CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non …
[HTML][HTML] Metabolic control of Treg cell stability, plasticity, and tissue-specific heterogeneity
H Shi, H Chi - Frontiers in immunology, 2019 - frontiersin.org
Regulatory T (Treg) cells are crucial for peripheral immune tolerance and prevention of
autoimmunity and tissue damage. Treg cells are inherently defined by the expression of the …
autoimmunity and tissue damage. Treg cells are inherently defined by the expression of the …
[HTML][HTML] Glutarate regulates T cell metabolism and anti-tumour immunity
E Minogue, PP Cunha, BJ Wadsworth, GL Grice… - Nature …, 2023 - nature.com
T cell function and fate can be influenced by several metabolites: in some cases, acting
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …
mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions
The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …
Cytokine‐regulated Th17 plasticity in human health and diseases
Upon activation, naïve CD4+ T helper (Th) cells differentiate into distinct Th effector cell
lineages depending on the local cytokine environment. However, these polarized Th cells …
lineages depending on the local cytokine environment. However, these polarized Th cells …