Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role
of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review …

In contrast to an obsolete notion that erythrocytes, or red blood cells (RBC s), play a passive
and minor role in haemostasis and thrombosis, over the past decades there has been …

A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …

As our knowledge of the structure and functions of fibrinogen and fibrin has increased
tremendously, several key findings have given some people a superficial impression that the …

Polyhedral erythrocytes, named polyhedrocytes, are formed in contracted blood clots and
thrombi, as a result of compression by activated contractile platelets pulling on fibrin. This …

Background and Purpose: The purpose was to assess quantitatively and qualitatively the
composition and structure of cerebral thrombi and correlate them with the signs of intravital …

Objective—Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic
stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction …

Essentials• Clot contraction influences the rate of fibrinolysis in vitro.• Internal fibrinolysis is
enhanced∼ 2‐fold in contracted vs. uncontracted blood clots.• External fibrinolysis is∼ 4 …