Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the
replication fork. DNA sliding clamps play an important role in this assembly and are …

Biological processes are the result of noncovalent, protein–ligand interactions, where the
ligands range from small organic and inorganic molecules to lipids, nucleic acids, peptides …

DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …

The initiation of DNA replication is typically tightly regulated by proteins that form initiation
complexes at specific sequences known as replication origins. In Archaea and Eukaryotes …

DNA replication and repair are essential biological processes needed for the survival of all
organisms. Although these processes are fundamentally conserved in the three domains …

The life span of a neutrophil is a tightly regulated process as extended survival is beneficial
for pathogen elimination and cell death necessary to prevent cytotoxic content release from …

Many aspects of and factors required for DNA replication are conserved across all three
domains of life, but there are some significant differences surrounding lagging-strand …

Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. Proliferating
cell nuclear antigen (PCNA) plays a pivotal role in cancer development and progression …

The base excision repair (BER) pathway repairs oxidized lesions in the DNA that result from
reactive oxygen species generated in cells. If left unrepaired, these damaged DNA bases …