Orally absorbed cyclic peptides
DS Nielsen, NE Shepherd, W Xu, AJ Lucke… - Chemical …, 2017 - ACS Publications
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …
Constraining cyclic peptides to mimic protein structure motifs
Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
The role of complement in biomaterial-induced inflammation
Biomaterials are regularly used in various types of artificial tissues and organs, such as
oxygenators, plasmapheresis equipment, hemodialysers, catheters, prostheses, stents …
oxygenators, plasmapheresis equipment, hemodialysers, catheters, prostheses, stents …
Function, structure and therapeutic potential of complement C5a receptors
PN Monk, AM Scola, P Madala… - British journal of …, 2007 - Wiley Online Library
Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …
activation of the complement cascade of serum proteins in response to foreign surfaces such …
Inhibiting the C5–C5a receptor axis
Activation of the complement system is a major pathogenic event that drives various
inflammatory responses in numerous diseases. All pathways of complement activation lead …
inflammatory responses in numerous diseases. All pathways of complement activation lead …
The role of the complement system in ischemia-reperfusion injury
Abstract Ischemia-reperfusion (I/R) injury is a common clinical event with the potential to
seriously affect, and sometimes kill, the patient. Interruption of blood supply causes …
seriously affect, and sometimes kill, the patient. Interruption of blood supply causes …
Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a
AM Finch, AK Wong, NJ Paczkowski… - Journal of medicinal …, 1999 - ACS Publications
Activation of the human complement system of plasma proteins during immunological host
defense can result in overproduction of potent proinflammatory peptides such as the …
defense can result in overproduction of potent proinflammatory peptides such as the …
Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure
JDA Tyndall, B Pfeiffer, G Abbenante… - Chemical …, 2005 - ACS Publications
G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins
(Figure 1) found on the surface of all cells. 1-3 They mediate cellular responses to a diverse …
(Figure 1) found on the surface of all cells. 1-3 They mediate cellular responses to a diverse …
Moving targets: cell migration inhibitors as new anti-inflammatory therapies
CR Mackay - Nature immunology, 2008 - nature.com
The pharmaceutical industry has targeted various types of molecules to subdue
inflammatory diseases. Drugs that disrupt cell migration appear particularly promising in …
inflammatory diseases. Drugs that disrupt cell migration appear particularly promising in …