The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of
pathophysiological conditions occurring in humans is here provided. Despite an active, now …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Since its discovery, the study of the biological role of α-synuclein and its pathological
implications has been the subject of increasing interest. The propensity to adopt different …

Lewy Body Disorders (LBDs) lie within the spectrum of age-related neurodegenerative
diseases now frequently categorized as the synucleinopathies. LBDs are considered to be …

Aggregation and neurotoxicity of misfolded alpha-synuclein (αSyn) are crucial mechanisms
for progressive dopaminergic neurodegeneration associated with Parkinson's disease (PD) …

Several observations have implicated oxidative stress and aggregation of the presynaptic
protein α-synuclein in the pathogenesis of Parkinson disease. α-Synuclein has been shown …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. Oxidative
damage has been associated with pathological neuronal loss in HD. The therapeutic …

Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several
neuronal synaptic functions in physiological and pathological conditions. Many studies, over …

Oxidative stress has been implicated in the etiology of neurodegenerative disorders with α-
synuclein pathology. Lipid peroxidation products such as 4-oxo-2-nonenal (ONE) and 4 …