A new perspective on NAFLD: Focusing on lipid droplets
E Scorletti, RM Carr - Journal of hepatology, 2022 - Elsevier
Lipid droplets (LDs) are complex and metabolically active organelles. They are composed of
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …
Regulation of innate immune cell function by mTOR
T Weichhart, M Hengstschläger, M Linke - Nature Reviews Immunology, 2015 - nature.com
The innate immune system is central for the maintenance of tissue homeostasis and quickly
responds to local or systemic perturbations by pathogenic or sterile insults. This rapid …
responds to local or systemic perturbations by pathogenic or sterile insults. This rapid …
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
VA Gerriets, RJ Kishton, MO Johnson, S Cohen… - Nature …, 2016 - nature.com
CD4+ effector T cells (Teff cells) and regulatory T cells (Treg cells) undergo metabolic
reprogramming to support proliferation and immunological function. Although signaling via …
reprogramming to support proliferation and immunological function. Although signaling via …
mTORC 1 and mTORC 2 as regulators of cell metabolism in immunity
M Linke, SD Fritsch, N Sukhbaatar… - FEBS …, 2017 - Wiley Online Library
The mechanistic target of rapamycin (mTOR) pathway is an evolutionarily conserved
signaling pathway that senses intra‐and extracellular nutrients, growth factors, and …
signaling pathway that senses intra‐and extracellular nutrients, growth factors, and …
LRRK2 regulation of immune-pathways and inflammatory disease
RL Wallings, MG Tansey - Biochemical Society Transactions, 2019 - portlandpress.com
Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
Phosphoinositide 3-kinase gamma inhibition protects from anthracycline cardiotoxicity and reduces tumor growth
Background: Anthracyclines, such as doxorubicin (DOX), are potent anticancer agents for
the treatment of solid tumors and hematologic malignancies. However, their clinical use is …
the treatment of solid tumors and hematologic malignancies. However, their clinical use is …
[HTML][HTML] Punicalagin regulates signaling pathways in inflammation-associated chronic diseases
Inflammation is a complex biological defense system associated with a series of chronic
diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative …
diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative …
[HTML][HTML] The lysosome signaling platform: adapting with the times
S Inpanathan, RJ Botelho - Frontiers in cell and developmental …, 2019 - frontiersin.org
Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …
phagocytosis. What once was viewed as a simple acidic organelle in charge of …
[HTML][HTML] The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation
Z Zhang, P Qin, Y Deng, Z Ma, H Guo, H Guo… - Journal of …, 2018 - Springer
Background The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection
against cerebral ischemic injury by activating estrogen receptors. The novel estrogen …
against cerebral ischemic injury by activating estrogen receptors. The novel estrogen …
[HTML][HTML] Regulation of mTORC1 by upstream stimuli
CH Melick, JL Jewell - Genes, 2020 - mdpi.com
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein
kinase that senses multiple upstream stimuli to control cell growth, metabolism, and …
kinase that senses multiple upstream stimuli to control cell growth, metabolism, and …